**[4-(4-hydroxyphenyl)phenyl]-phenylmethanone** is a chemical compound with the molecular formula C19H14O2. It is also known as **4'-hydroxybenzophenone**.
**Structure and Properties:**
* **Structure:** The molecule consists of three aromatic rings connected by a carbonyl group. One of the aromatic rings has a hydroxyl group (OH) attached to it.
* **Appearance:** It is a white to off-white solid at room temperature.
* **Solubility:** It is soluble in organic solvents such as ethanol and acetone but sparingly soluble in water.
**Importance in Research:**
**1. Photoinitiator for Polymerization:**
* 4'-hydroxybenzophenone is a widely used **photoinitiator** in various polymerization processes, such as **free radical polymerization**.
* It absorbs UV light and generates free radicals, which initiate the polymerization reaction.
**2. UV Absorber:**
* The molecule possesses a strong **UV absorption** property due to its conjugated system.
* It is used as a **UV absorber** in sunscreens, cosmetics, and polymers to protect against harmful UV radiation.
**3. Pharmaceutical Applications:**
* 4'-hydroxybenzophenone has been investigated for its potential **pharmacological activity**, including:
* **Anti-inflammatory:** It exhibits anti-inflammatory properties and may be useful in treating inflammatory conditions.
* **Antioxidant:** It acts as an antioxidant and may help protect cells from oxidative damage.
**4. Organic Synthesis:**
* It is an important **intermediate** in the synthesis of various organic compounds, including pharmaceuticals and other fine chemicals.
**5. Materials Science:**
* 4'-hydroxybenzophenone has applications in **materials science**, such as in the development of **photoresists** for microelectronics fabrication.
**6. Environmental Research:**
* The compound has also been studied in environmental research, as it can be found in **wastewater** and may have potential **environmental effects**.
**Overall, [4-(4-hydroxyphenyl)phenyl]-phenylmethanone (4'-hydroxybenzophenone) is an important compound with diverse applications in various fields, including photochemistry, polymer science, pharmaceutical research, and materials science.**
ID Source | ID |
---|---|
PubMed CID | 344075 |
CHEMBL ID | 1341020 |
CHEBI ID | 114504 |
SCHEMBL ID | 2214895 |
Synonym |
---|
5623-46-1 |
mls000757167 , |
nsc400770 |
nsc-400770 |
smr000529026 |
CHEBI:114504 |
[4-(4-hydroxyphenyl)phenyl]-phenylmethanone |
IURCXIQRULDEEY-UHFFFAOYSA-N |
4-hydroxy-4'-benzoylbiphenyl |
CHEMBL1341020 |
SCHEMBL2214895 |
Q27195907 |
DTXSID20322251 |
(4'-hydroxy[1,1'-biphenyl]-4-yl)phenylmethanone |
nsc 400770 |
Class | Description |
---|---|
benzophenones | Any aromatic ketone in which the carbonyl group is bonded to 2 phenyl groups. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Luciferase | Photinus pyralis (common eastern firefly) | Potency | 16.9441 | 0.0072 | 15.7588 | 89.3584 | AID588342 |
glp-1 receptor, partial | Homo sapiens (human) | Potency | 12.5893 | 0.0184 | 6.8060 | 14.1254 | AID624417 |
ATAD5 protein, partial | Homo sapiens (human) | Potency | 18.4706 | 0.0041 | 10.8903 | 31.5287 | AID504466; AID504467 |
67.9K protein | Vaccinia virus | Potency | 2.2387 | 0.0001 | 8.4406 | 100.0000 | AID720579 |
P53 | Homo sapiens (human) | Potency | 17.7828 | 0.0731 | 9.6858 | 31.6228 | AID504706 |
IDH1 | Homo sapiens (human) | Potency | 18.3564 | 0.0052 | 10.8652 | 35.4813 | AID686970 |
nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 29.0929 | 0.0041 | 9.9848 | 25.9290 | AID504444 |
ras-related protein Rab-9A | Homo sapiens (human) | Potency | 3.1623 | 0.0002 | 2.6215 | 31.4954 | AID485297 |
nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 10.6655 | 0.0079 | 8.2332 | 1,122.0200 | AID2546; AID2551 |
geminin | Homo sapiens (human) | Potency | 19.7347 | 0.0046 | 11.3741 | 33.4983 | AID624296; AID624297 |
DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 0.6310 | 0.0580 | 10.6949 | 26.6086 | AID602310 |
lamin isoform A-delta10 | Homo sapiens (human) | Potency | 6.3096 | 0.8913 | 12.0676 | 28.1838 | AID1487 |
TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 7.0795 | 1.7783 | 16.2081 | 35.4813 | AID652104 |
Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 100.0000 | 3.9811 | 46.7448 | 112.2020 | AID720708 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 3 (60.00) | 24.3611 |
2020's | 1 (20.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.56) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |